J Sports Med Phys Fitness. 2015 Jul 14. [Epub ahead of print]
Effect of single injection of Platelet-Rich Plasma in comparison with
corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial.
Forogh B(1), Mianehsaz E, Shoaee S, Ahadi T, Raissi GR, Sajadi S.
Author information:
(1)Firouzgar Hospital, Physical Medicine and Rehabilitation Department, Iran
University ofMedical Sciences, Tehran, Iran - grezaraissi@yahoo.com.
AIM: Evidence on the effect of Platelet-Rich Plasma (PRP) in treating
osteoarthritis (OA) is insufficient. Therefore, the present study compares the
effects of a one-time injection of PRP and corticosteroid (CS) as two types of
treatment for the patients suffering from osteoarthritis.
METHODS: In the present randomized double blind clinical trial, the participants
who suffered from knee osteoarthritis (Grades II/III), were randomly divided into
two groups: intra articular injection of PRP and CS. Knee injury and
osteoarthritis outcome score (KOOS), the 20-meter-walk test, active and passive
ranges of motions (ROM), flexion contracture, and pain intensity based on Visual
Analog Scale (VAS) were assessed before, 2-months, and 6-months after
interventions.
RESULTS: 41 participants (48 knees) were involved in the research (66.7% women;
average age of 61.1±7.0 years old). Compared to the group treated with
corticosteroid, pain relief (df:6 ,35 ;F=11.0 ;p=0.007), symptom free (df:6 ,35
;F=23.0 ;p<0.001), activities of daily living (ADL) (df:6 ,35 ;F=10.7 ;p=0.005)
and quality of life (df:6 ,35 ;F=5.2 ;p=0.02) in the RPR group were significantly
higher, but sporting ability was not different between the 2 groups (df:6 ,35
;F=0.6 ;p=0.55). PRP prescription was significantly more helpful for relieving
patients' pain (VAS) compared to corticosteroids (df:6,35;F=32.0 ;p,0.001).It's
also notable that using PRP was more helpful in improving the 20-meter-walk test
than corticosteroid treatment (df:6 ,35 ;F=7.4 ;p=0.04) but none of the
treatments had any impact on active flexion ROM ،passive flexion ROM and flexion
contracture (p>0.05).
CONCLUSION: Our study demonstrated that one shot of PRP injection, decreased
joint pain more and longer-term, alleviated the symptoms, and enhanced the
activity of daily living and quality of life in short-term duration in comparison
with CS.
PMID: 26173792 [PubMed - as supplied by publisher]
